Immunogenesis in Lassa fever and prospects for vaccine development

Analysis of literature data on the structure Lassa virus genome and its strain diversity has shown that molecular heterogeneity strains is essential in design vaccines evaluation their efficacy, which determined by relevant WHO recommendations. During reproduction, counteracts cellular immunogenesis suppressing expression suppressor signaling proteins, cytokines RLR receptor recognizes viral two-segmented RNA.
 The GP protein, determines pathogen's infectivity tropism, should be main target for being developed. Other targets are processes RNA synthesis determine features immunogenesis. A study fever shows preferred candidate would a replicating apathogenic vaccine capable inducing an optimal combination humoral responses, is, causing high activity T-lymphocytes production neutralizing antibodies. One most important characteristics live genetic stability to exclude reversion more pathogenic genotype.
 Of than 130 against designed, only two promising were tested immunogenicity safety humans (a recombinant measles platform DNA vaccine). with vesicular stomatitis reassortants Mopeya viruses (MOPV/LASV- ML29) (r3ML29) further development. rVSVG/LVGPC, similar rVSVG-ZEBOV-GP Ebola, promising.